A Beacon of Hope: Kendric’s Journey Towards a Cure Sickle Cell Gene Therapy

**A Beacon of Hope: Kendric’s Journey Towards a Cure**

In the bustling suburbs of Washington, D.C., resides a 12-year-old boy named Kendric Cromer. His youthful spirit belies the weight of a formidable adversary: sickle cell disease. For Kendric, and thousands like him across the United States, every day has been a battle against debilitating pain and shattered dreams. But now, a glimmer of hope shines on the horizon as Kendric embarks on a groundbreaking medical journey.

On a Wednesday that will be etched into history, Kendric became the first person worldwide with sickle cell disease to undergo a commercially approved gene therapy aimed at curing this relentless condition. The significance of this milestone cannot be overstated. For the estimated 20,000 individuals in the U.S. eligible for this treatment, Kendric’s journey offers not just optimism but tangible possibilities.

Kendric's
Bone marrow stem cells, the source of all of the body’s red and white blood cells, are normally nestled in the marrow, but Kendric’s doctors infused him with a drug, plerixafor, that pried them loose and let them float in his bloodstream.
Kendric's
Bluebird is charging $3.1 million for its gene therapy, called Lyfgenia. It’s one of the highest prices ever for a treatment.

For Kendric, sickle cell has been a thief of joy, robbing him of the simple pleasures of childhood. Ordinary activities like riding a bike or playing soccer often morph into agonizing episodes of pain. But now, with the promise of gene therapy, Kendric dares to dream of a normal life—a life free from the clutches of sickle cell disease.

The road to this groundbreaking treatment began with the Food and Drug Administration’s authorization for two companies to offer gene therapy to sickle cell patients. Kendric’s treatment marks a significant milestone for Bluebird Bio, a company based in Somerville, Mass. While another company, Vertex Therapeutics, also received approval for its CRISPR-based remedy, details about its patient treatments remain undisclosed.

Keith Cromer, Kendric’s father. He and his wife, Deborah, were told when she was pregnant that Kendric had a one-in-four chance of developing sickle cell disease
Deborah Cromer, Keith’s mother. “We always prayed this day would come,” she said. But, she added, “We’re nervous reading through the consents and what he will have to go through.”

At the forefront of this medical revolution is Kendric, whose family’s health insurance has graciously agreed to cover the procedure. His journey commenced at Children’s National Hospital in Washington, where doctors embarked on the first phase of treatment. Stem cells from Kendric’s bone marrow were meticulously extracted, a process requiring hours of delicate work.

The subsequent steps are no less arduous. Bluebird Bio’s specialized lab will genetically modify Kendric’s stem cells, a meticulous process that spans several months. If initial collections fall short, additional extractions may be necessary, prolonging the journey towards a cure.

The complexity of gene therapy underscores the challenges faced by medical centers and patients alike. With a limited capacity to treat patients, each step demands expert care and attention. For Kendric and others undergoing this transformative treatment, the road ahead is paved with uncertainty and hope in equal measure.

For Kendric, gene therapy represents more than just a cure—it’s a lifeline to a future he once thought unattainable. Despite the astronomical cost and grueling process, patients like Kendric are willing to endure it all for the chance at a life free from pain and limitations.

But Kendric’s journey is not just about overcoming sickness; it’s about resilience, hope, and the unwavering support of loved ones. His parents, Deborah and Keith, have stood by him every step of the way, their unwavering devotion a beacon of strength in the face of adversity.

For Kendric, the dream of a future without pain is within reach. As he looks ahead, he envisions a world where he can pursue his passions without fear or limitation. A future where he can play basketball with abandon and aspire to become a geneticist—an ambition fueled by his own journey towards healing.

In the hearts of Kendric and countless others battling sickle cell disease, hope burns bright. With each step towards a cure, they stand as beacons of courage and determination, reminding us all that even in the darkest of times, there is always hope for a brighter tomorrow.

Leave a Comment